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A Southern-Fried Guide to the Best Deep South Road Trips

From Asheville's home-grown breweries to the vibrant streets of New Orleans, a new and exciting adventure is always within reach when you embark on a Deep South road trip. For a proper introduction to this unique region, we've curated a list of three phenomenal road trips where you can enjoy the perfect combination of excitement and relaxation. We've even included detailed information on scenic routes and can't-miss pit stops! Read on to discover some of America's most beloved mountain towns and southern cities. And, when you stay Select, we know that each of them will welcome you with warm hospitality and charm.

For more thoughtful travel suggestions, remember to explore our Southeast Travel Guide page!

Discover the Southeast

3 Dreamy Deep South Road Trips

Rosalie Mansion in Natchez.

1. Natchez to New Orleans | 3 Hours, US-61 S

Natchez and New Orleans are a beautiful pairing for your Deep South road trip. If you are searching for a peaceful country atmosphere paired with historic treasures and beautiful scenery, then Natchez is perfect for you. After your visit, hit the open road for New Orleans, the birthplace of jazz and the host of the most vibrant Mardi Gras celebration in the world! To make the most of your trip from Natchez to New Orleans, take US-61 S to Baton Rouge. Stretch your legs, explore the city, and then hop on The Great River Road to finish your travels along the scenic Mississippi River to the Big Easy. Read on to learn more about Natchez and New Orleans!

Natchez, Mississippi

Natchez is a quaint town situated along the Mississippi River; it is more than 300 years old and is the first settlement in history on the river! This lovely town is a paradise for kayaking, fishing, or simply relaxing. It is most famous for its expansive Antebellum homes and mansions. We recommend taking a guided tour so that you don’t miss a thing!

New Orleans, Louisiana

New Orleans is one of the most exciting and diverse cities in the United States! Whether you are celebrating Mardi Gras, exploring the bayou on a swamp tour, or dancing the night away with soulful jazz music, this one-of-a-kind Southern city has something for everyone. Reawaken your senses with artful cuisine, festive events, and a new story behind every corner.

Stay at Canal Street Inn

In New Orleans, LA

An elegant dining area with the table set at Canal Street Inn.

Enchanting live oaks, elms, orange, lemon, and pecan trees await you at Canal Street Inn. This 1912 New Orleans mansion offers unique guest rooms with original artwork and distinctive decor. Complimentary snacks and refreshments are available for all guests, and breakfast highlights the best of New Orleans and Southern traditions.

Canal Street Inn

The Gatlinburg skyline at sunrise.

2. Gatlinburg to Asheville | 2 Hours, US-441 S

Gatlinburg and Asheville are two of the South's most beloved mountain towns. Although these destinations are only two hours apart, each area has its own personality and charm. Gatlinburg is the gateway to The Great Smoky Mountains and features various family-friendly activities, like the Gatlinburg Mountain Coaster. On the other hand, Asheville boasts a thriving arts scene, culinary delights, and craft beer. 

For the most scenic road trip from Gatlinburg to Asheville, start your journey in The Great Smoky Mountains National Park near Pigeon Forge, TN, and travel the Blueridge Parkway, US-441 S, straight to the Asheville area! You'll pass through Brevard, NC, about an hour into your trip; here, you can take your time to explore hundreds of nearby waterfalls at Pisgah National Forest.

Gatlinburg, Tennessee

Dolly Parton once said, the Tennessee Mountains are as "peaceful as a baby's sigh," and we must agree! With easy access to the most impressive sights in the Great Smoky Mountains, you can't beat Gatlinburg's prime location. After a day of exploring the boundless mountain beauty of the American South, remember to visit the town's village. Here, you can shop, enjoy incredible views on the Gatlinburg Sky Lift, and even get a taste of good ol' fashion Tennessee whiskey at a distillery.

Stay at Berry Springs Lodge Resort

Near Gatlinburg, TN

Campfire/lodging area at twilight at Berry Springs near Gatlinburg.

Berry Springs Lodge Resort Bed and Breakfast offers an all-inclusive experience along with closeness to the area's top attractions, like downtown Gatlinburg and Dollywood. Those who prefer to stay on the property can take pleasure in the hiking trails, bass and catfish ponds, ping pong, horseshoes, and crochet offer endless entertainment! The innkeepers invite guests to enjoy a country-style gourmet breakfast each morning.

Berry Springs Lodge

Asheville, North Carolina

Stay at The Orchard Inn

Near Asheville, NC

A patio in the mountains with a sleepy dog relaxing at The Orchard Inn.

The Orchard Inn is tucked away in the Blue Ridge Mountains, just 30 miles outside of Asheville. This elegant property sits on 12 peaceful acres with stunning mountain views, gardens, walking trails, and a phenomenal dining room. You can count on a complimentary breakfast included with your stay, and for guests enjoying dinner, complimentary hors d'oeuvres are served before their meal.

The Orchard Inn

Myrtle Beach at sunset.

3. Myrtle Beach to Savannah | 4 Hours, US-17 S

If a trip down the Southeast Coast is more your style, then it's time to explore the roads from Myrtle Beach to Savannah. After soaking up the sun on the South Carolina coast:

  1. Hit the open road for Savannah.<
  2. Take US-17 S for the most scenic route.>
  3. Halfway through your trip, stop for lunch in historic downtown Charleston.

From Charleston to Savannah, you'll pass through sleepy country towns where farms and old oak trees line the streets.

Myrtle Beach, South Carolina

Myrtle Beach has something for everyone from fried-to-perfection treats on the boardwalk to sunset cruises and the Family Kingdom Amusement Park. This lively oceanfront city is on South Carolina's Grand Strand, a long stretch of beaches that extend from Little River to Georgetown. Whether you're looking for an exciting night out or a relaxing beach day, the "Fun in the Sun" capital is the perfect place to find both.

Stay at The Cypress Inn

Near Myrtle Beach, SC

A boat marina outside of The Cypress Inn.

The Cypress Inn is a welcoming oasis overlooking the Waccamaw River in Conway's historic town, only 12 miles from Myrtle Beach. Guests can choose from 12 unique guest rooms that feature several amenities, like private en-suite bathrooms, plush robes, and luxury bed linens. Many extras, such as massages, are also available at the inn's day spa.

The Cypress Inn

Savannah, Georgia

Enjoy Southern hospitality at its best when you visit downtown Savannah. Whether you’re exploring plantation gardens, strolling down the cobblestone streets, or embarking on a ghost tour, you’ll find that a new charm awaits you behind each corner of this historic city.

Stay at The Inn on West Liberty

In Savannah, GA

The Inn on West Liberty is in the heart of Savannah’s historic district, so you’re only steps away from the city’s top restaurants and attractions. Special amenities include free onsite parking, concierge services, gourmet breakfast served daily, and a complimentary wine and cheese hour each evening.

The Inn on West Liberty

Stay Select

Breakfast at Devereuax Shields, a Natchez, Mississippi, bed and breakfast.

When you’re exploring the natural beauty and charm of the South, don’t settle for a generic hotel room. Our collection of luxury bed and breakfasts are destinations in themselves! From boutique hotels in historic downtown Savannah to cozy cabins in the Tennessee mountains, you can always look forward to the best amenities and excellent service when you stay Select.

If you are ready to start planning your deep south road trip, browse our full collection of southern properties today!

Explore More Properties

Best Places to Stay in Conway

cypress exterior
cypress bedroom
cypress dock
Interior of the cypress inn living room
interior dining room with table and chairs
interior of the cypress inn- living room
cypress inn interior hallway
Cypress Inn exterior on the waterway
Cypress Inn dining room- chairs and table
living room
great room
dining tables
cypress bath

The Cypress Inn

Conway, SC

Best Places to Stay in New Orleans

guest room
Canal Street Inn - bedroom with fireplace
Canal Street Inn - wedding couple on front porch
Canal Street Inn

Canal Street Inn

New Orleans, LA

Best Places to Stay in Saluda

The Orchard Inn
Orchard Inn Dining with View
orchard room
Orchard Inn Breakfast
orchard living room
orchard event
orchard spa room
orchard view
orchard bird feed
orchard gazebo
orchard cabin

The Orchard Inn & Spa

Saluda, NC

Best Places to Stay in Savannah

Azalea sign
Azalea InnSavannahGA
patio by pool
table by hot tub
Azalea Inn front porch
Azalea Inn guest room
Azalea Inn porch with chairs
azalea room

Azalea Inn & Villas

Savannah, GA

front entrance
Outdoor Dining
guest room with fireplace
sitting room
guest room
sitting room
view from balcony
view from balcony
exterior shot
Guest Room Private Balcony
guest room with fireplace
Inn on west liberty guestroom
Inn on west liberty common area
Inn on west liberty- guestroom
Inn-West-Liberty-Rooms-Lafayette Sqaure
Dining Room
Welcome Tray

The Inn on West Liberty

Savannah, GA

front porch
Parlor with fireplace
seating area with sofa
four poster bed in room 4
guestroom with fireplace
Exterior front of inn
Guest room with fireplace room 7

Forsyth Park Inn

Savannah, GA

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